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A generic drug is actually its brand-name equivalent, although it doesnt bear the original trademark and looks slightly different.
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This is accounted for by the possible differences in their inactive ingredients such as color and flavor additives, and by the copyright and trademark regulations that does not allow for exact copies of the existing brand-name products.
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Ritonavir is most frequently used and recommended as a PK enhancer of more potent and better tolerated protease inhibitors.
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Plasma levels may be reduced by darunavir and ritonavir, decreasing the efficacy.
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A generic drug is usually called by the name of the active ingredient while a manufacturer uses a brand name.
Dosage adjustments necessary in patients with severe renal impairment.
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For study 2 (once-daily dosing), the pharmacokinetic profiles obtained during the first 12 h after the evening dose on day 13 were used to estimate C max and C min for the equivalent dosage administered twice daily.
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When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolution must be given within a month of the last dose of the former medication.
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Data from an AIDS Clinical Trials Group (ACTG A5143)-sponsored study concluded that the combination of fosamprenavir, lopinavir, and ritonavir results in marked reductions in plasma concentrations of amprenavir and lopinavir (Kashuba, 2003).
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Do not give EXVIERA with certain drugs that are strong inhibitors of CYP2C8.
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Grade 1 side effects are mild and transient, grade 2 side effects are moderate or persistent, grade 3 adverse events are severe, and grade 4 side effects are life-threatening.
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Concomitant EIAEDs and not valproate: 50mg daily for 2 weeks, then 100mg daily in divided doses for 2 weeks, then increase weekly by 100mg daily in divided doses to target dose of 400mg daily in divided doses.
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